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Conhecido por seu papel no crescimento de?? todos os tecidos do corpo humano, o horm�nio do crescimento (GH, da sigla em ingl�s growth hormone) � tamb�m um?? poderoso ansiol�tico. Um estudo realizado por pesquisadores da Universidade de S�o Paulo (USP) aprofundou o entendimento sobre a capacidade do?? GH em reduzir a ansiedade e, pela primeira vez, identificou a popula��o de neur�nios respons�vel por modular os efeitos do?? horm�nio em doen�as neuropsiqui�tricas, como o transtorno de ansiedade, depress�o e estresse p�s-traum�tico.

No trabalho, apoiado pela FAPESP, os pesquisadores observaram?? que, ao retirar o receptor de GH de c�lulas neuronais que expressam o pept�deo somatostatina (um antagonista do horm�nio de?? crescimento), houve um aumento do comportamento semelhante � ansiedade em camundongos machos.

Os testes demonstraram ainda uma redu��o da mem�ria do?? medo em animais de ambos os sexos. A descoberta pode permitir que no futuro novas classes de medicamentos ansiol�ticos sejam?? desenvolvidas.

�A descoberta sobre o mecanismo envolvendo o efeito ansiol�tico do GH abre caminho para uma poss�vel explica��o � meramente qu�mica?? � sobre esses dist�rbios e por que em situa��es com maior ou menor secre��o do horm�nio do crescimento os indiv�duos?? apresentam maior ou menor preval�ncia desses dist�rbios�, afirma Jos� Donato J�nior, professor do Instituto de Ci�ncias Biom�dicas da Universidade de?? S�o Paulo (ICB-USP) e autor do artigo publicado no The Journal of Neuroscience.

No estudo, os pesquisadores utilizaram tr�s tipos de?? experimentos com os camundongos (campo aberto, labirinto em cruz elevado e caixa claro-escuro) para testar a capacidade dos animais de?? explorar o ambiente e de se colocar em risco. �S�o experimentos bem estabelecidos e que medem o comportamento do animal?? semelhante � ansiedade e � mem�ria de medo (que est� por tr�s dos movimentos de estresse p�s-traum�tico). Com isso, foi?? poss�vel verificar os efeitos do horm�nio GH nesses animais�, explica Donato.

O pesquisador afirma que ainda n�o se sabe por que?? no estudo n�o houve aumento de comportamento semelhante � ansiedade em camundongos f�meas. �Acreditamos que seja pelo fato de haver?? um dimorfismo sexual. Sabemos que a estrutura nessa �rea do c�rebro onde est�o os neur�nios que estudamos � um pouco?? diferente entre machos e f�meas. N�o por acaso, alguns transtornos s�o diferentes entre homens e mulheres�, diz.

A parte qu�mica

Milhares de?? pessoas sofrem de doen�as neuropsiqui�tricas em todo o mundo. Embora ansiedade e depress�o estejam entre os transtornos mais comuns, ainda?? n�o est� totalmente esclarecido quais s�o as causas exatas para esses problemas. Acredita-se, inclusive, que possa ser uma combina��o de?? fatores entre estresse, gen�tica, press�es sociais, econ�micas, de g�nero, entre outros que possam contribuir para a ocorr�ncia desses transtornos.

Evid�ncias crescentes?? sugerem que os horm�nios tamb�m podem desempenhar um papel importante na regula��o de diversos aspectos neurol�gicos, modificando assim a predisposi��o?? a esses dist�rbios.

Altera��es nos n�veis de horm�nios sexuais como o estradiol, por exemplo, afetam comportamento semelhante a ansiedade ou depress�o?? e mem�ria de medo em roedores e humanos. Outros estudos, ainda preliminares, demonstraram que os glicocorticoides (horm�nios sintetizados a partir?? do cortisol) podem estar envolvidos no surgimento de doen�as neuropsiqui�tricas.

Pelo menos no caso do GH ainda n�o havia sido identificado?? o mecanismo de regula��o do horm�nio em neur�nios associados a doen�as neuropsiqui�tricas. �Demonstramos que o horm�nio do crescimento muda a?? sinapse alterando estruturalmente os neur�nios que secretam somatostatina�, relata o pesquisador.

No estudo, os pesquisadores comprovaram ainda que transtorno de ansiedade,?? mem�ria de medo e estresse p�s-traum�tico s�o faces diferentes de um mesmo circuito neuronal.

Vale destacar que a ansiedade pode ser?? definida como um medo excessivo (falta de confian�a). J� a mem�ria do medo, explica Donato, est� relacionada a algum evento?? negativo que gera uma resposta (uma altera��o no c�rebro) e toda vez que o animal ou o indiv�duo � exposto?? novamente � mesma situa��o h� uma rea��o exagerada de medo, podendo haver paralisia ou outros sintomas, como choro excessivo ou?? tremedeira.

�Tudo isso acontece na mesma popula��o de neur�nios. S�o eles que expressam o receptor de GH e quando, no nosso?? experimento, desligamos esse receptor os animais tiveram uma redu��o na forma��o de mem�ria do medo. Isso significa que a capacidade?? de forma��o dessa mem�ria de medo fica prejudicada. Pode ser que em situa��es de estresse p�s-traum�tico o GH seja um?? fator que contribua para o desenvolvimento desses transtornos�, diz.

Isso porque uma sucess�o de estresse cr�nico eleva outro horm�nio denominado grelina?? � um potente estimulador da secre��o de GH. �A grelina j� vem sendo estudada no estresse p�s-traum�tico h� bastante tempo?? e alguns estudos demonstraram que � justamente essa secre��o de GH induzida pela grelina que est� aumentada no estresse cr�nico.?? Isso favorece o desenvolvimento da mem�ria de medo e estresse p�s-traum�tico no c�rebro do animal.�

Horm�nio e preval�ncia de transtornos

Em humanos,?? o horm�nio do crescimento � secretado pela hip�fise e liberado na corrente sangu�nea, promovendo o crescimento de tecidos em todo?? o corpo humano por meio de forma��o proteica, multiplica��o celular e diferencia��o celular. Trata-se de um horm�nio indispens�vel durante o?? per�odo de crescimento. Ele � secretado principalmente durante a inf�ncia e adolesc�ncia. H� tamb�m um pico de secre��o durante a?? gravidez. Depois, na velhice, h� uma queda natural de GH.

Problemas emjogo bolinha blazesecre��o acarretam o nanismo, por exemplo, que se?? manifesta principalmente a partir dos 2 anos de idade, impedindo o crescimento e desenvolvimento durante a inf�ncia e adolesc�ncia.

�Estudos anteriores?? realizados em seres humanos deficientes em GH j� haviam demonstrado maior preval�ncia de depress�o e ansiedade nesses indiv�duos. Mas a?? causa disso ainda n�o foi estabelecida. Alguns autores atribu�am essa alta preval�ncia a problemas de imagem e bullying provenientes da?? baixa estatura�, conta Donato.

O pesquisador ressalta que o estudo realizado em camundongos permite verificar o papel-chave do horm�nio do crescimento?? no problema, sem o impacto de outras vari�veis, como, por exemplo, problemas de imagem.

�Nosso estudo permitiu saber at� que ponto?? se trata de um efeito direto do horm�nio e at� que ponto � uma a��o indireta do d�ficit de crescimento.?? Como conseguimos identificar o mecanismo envolvendo o GH, sabemos que ele � uma causa direta do problema de transtorno de?? ansiedade e, assim, fica mais f�cil come�ar a pensar em terapias�, afirma.

Donato conta que o grupo agora vai direcionar os?? estudos do GH para o per�odo da gravidez. �� durante a gesta��o que ocorre um boom do GH. E �?? tamb�m ap�s esse per�odo que ocorre uma alta na preval�ncia de casos de depress�o � a depress�o p�s-parto. � claro?? que existem press�es sociais, econ�micas e outras relacionadas a esses tipos de transtornos. No entanto, n�o podemos esquecer que s�o?? per�odos de um boom hormonal que podem desregular o funcionamento do c�rebro, acarretando esses transtornos�, diz.

Quadro que causa dor prolongada?? e intensa na regi�o peitoral pode ocorrer devido � forma��o de co�gulos que interrompem o fluxo sangu�neo no cora��o; saiba?? mais

Comunidades de picopl�ncton s�o indicadores de sa�de ecol�gica e fornecem dados sobre o impacto das mudan�as clim�ticas; nova pesquisa mapeou?? os mecanismos e a distribui��o das esp�cies nos oceanos

Resid�ncia com decora��o sofisticada e v�rios andares apresenta pelo menos tr�s fases?? de constru��o, datando do final do s�culo 2 a.C ao final do s�culo 1 a.C.

Lista re�ne conjuntos de blocos de?? montar que reproduzem plantas, arquiteturas famosas e at� mesmo uma guitarra; pre�os come�am em R$ 324

Pelo 18� ano, o Grupo?? L'Or�al no Brasil reafirma o compromisso de dar destaque �s mulheres em carreira cient�fica e anuncia as vencedoras do pr�mio?? Para Mulheres na Ci�ncia, um programa realizado em parceria com a UNESCO no Brasil e a Academia Brasileira de Ci�ncias?? (ABC)

Hemangioma cavernoso fez Andressa Cordeiro ter hemorragias e perder um dos olhos e parte do l�bio e do nariz; em?? cirurgia, equipe m�dica removeu o tumor e agora atua para reconstruir seu rosto

Homenageada como �protetora da Amaz�nia�, ministra do Meio?? Ambiente e Mudan�a do Clima trouxe esperan�a com queda do desmatamento em ano de desastres clim�ticos, aponta influente revista cient�fica

Pesquisadores?? detectaram estrela que pode ampliar nossa compreens�o sobre a forma��o de exoplanetas e outras estrelas no aglomerado IC 348, a?? cerca de mil anos-luz

Pesquisadores da USP identificam, em testes realizados em camundongos, quais neur�nios est�o relacionados com o efeito ansiol�tico?? do horm�nio GH

Felinos de vida livre n�o consomem s� ratos: eles comem milhares de esp�cies, das quais quase 17% est�o?? em situa��o de "conserva��o preocupante", segundo pesquisa

� 1996 - 2023. Todos direitos reservados a Editora Globo S/A. Este material n�o?? pode ser publicado, transmitido por broadcast, reescrito ou redistribu�do sem autoriza��o.

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    Original release
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